The anticipated work project supports a DFG funded central project involved in standardized virus preparations and physiologically relevant cell culture systems which are essential for reproducible and comparable studies of human adenoviruses (HAdVs). Such resources enable investigations into viral pathogenesis, virus–host interactions, and the development of diagnostics, antiviral therapies, and safer gene therapy vectors. To support these goals, the aim is to establish harmonized virus stocks by generation and optimization of HAdV preparations, including wild-type, genetically modified, and replication-deficient viruses, focusing on clinically relevant HAdV types.
Furthermore, the project involves modern vector design including the generation of capsid modified adenoviruses, directed evolution approaches and optimizing the production of advanced high-capacity adenoviral vectors for gene therapeutic approaches.
Besides these tasks the successful candidate will be involved in teaching of students in virology and microbiology and in supervising visiting students.